• Compounds that induce exocytosis in cultured cells include

  2021-11-01

  

  Compounds that induce exocytosis in cultured autophagy pathway include Ca2+-dependent [14] or Ca2+-independent [15] mechanisms. Ca2+-dependent exocytosis releases soluble enzyme content from lysosomes [16] operating by increasing the cytosolic concentration of Ca2+[13] by recruiting extracellular C

• Acknowledgements br Introduction Histamine mediates various

  2021-11-01

  

  Acknowledgements Introduction Histamine mediates various physiological functions and pathological actions through its interactions with histamine receptors that belong to the superfamily of seven transmembrane G-protein-coupled receptors (GPCRs) (Haas et al., 2008). Four histamine receptor subty

• In cancer cells HIF upregulates HK II expression by

  2021-11-01

  

  In cancer cells, HIF-1α upregulates HK-II expression by binding to the hypoxia-responsive element in the HK-II promoter region to adapt to hypoxic conditions [20]. In the present study, we observed that mangiferin transiently increased HIF-1α expression in endothelial cells, suggesting another possi

• The HCV NS A protease consists of two subunits NS

  2021-11-01

  

  The HCV NS3/4A protease consists of two subunits, NS3 and NS4A. NS3 comprises an N-terminal serine protease domain and a C-terminal RNA helicase domain [12]. NS4A acts as a cofactor, which ties the holoenzyme complex to an intracellular membrane compartment. The presence of the central region of NS4

• A number of synthetic GPR agonists have been reported

  2021-10-29

  

  A number of synthetic GPR119 agonists have been reported to date, several of which have advanced into clinical trials. Reported GPR119 agonists are often composed of three parts as depicted in : a piperidine or a piperazine ring -substituted with a carbamate or a heteroaryl group at the right side,

• A further generally applicable approach for

  2021-10-29

  

  A further generally applicable approach for the synthesis of N-linked glycopeptides involves the convergent Lansbury aspartylation of glycosylamines. Here, the detrimental formation of aspartimides during the activation of the side chain aspartate can be prevented through the use of Ser/Thr pseudopr

• br Materials and methods br

  2021-10-29

  

  Materials and methods Results Discussion Here, we investigated the inhibitory effects and associated mechanisms of phloroglucinol on α-glucosidase. Our results showed that phloroglucinol reversibly inhibited α-glucosidase in a dose-dependent manner (Fig. 1), with the double-reciprocal plot

• Free fatty acids FFAs which are

  2021-10-29

  

  Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Furosemide mg receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Shor

• However despite medicinal chemistry efforts lead to consider

  2021-10-28

  

  However, despite medicinal chemistry efforts lead to considerable improvement in potency and selectivity of new HO-1 inhibitors, still have not identified inhibitors in the low nanomolar range. Therefore, due to the possible in vivo non-specific effects at high dosage, novel strategies should be dev

• br Introduction Few decades after of

  2021-10-28

  

  Introduction Few decades after of HIV/AIDS diagnosis, it has been still a health problem and impact will continue in the next decades. In 2015, HIV/AIDS was the 12th cause of death in the world and it's estimated that 1.2 million people was died of HIV/AIDS this year. In the global epidemiologica

• br Conflicts of interest br Funding This

  2021-10-28

  

  Conflicts of interest Funding This work was supported by the National Natural Science Foundation of China (No.81670558; 81800542), and the Science & Technology Development Fund of Tianjin Education Commission for Higher Education (No.2017KJ221). Acknowledgements Introduction Free fatty

• 5-Methoxy-CTP PBI is an agonist of GPR and acts as

  2021-10-28

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• Indeed our immunohistochemical analysis of skin tissue

  2021-10-28

  

  Indeed, our immunohistochemical analysis of skin tissue samples without any pathology confirmed the expression of MR and GR. Extending earlier findings in rats (Shaqura et al., 2016a, Shaqura et al., 2016b), we demonstrate here that MR mainly colocalize with the nociceptive neuronal marker CGRP sugg

• carboxypeptidase b There is a dual inducer of both galanin a

  2021-10-28

  

  There is a dual inducer of both galanin and super-threshold pain. First, injury-induced pain may stimulate galanin secretion. After peripheral nerve injury, the galanin expression level was upregulated in dorsal root ganglion (DRG), dorsal horn and hypothalamic arcuate of rats [25], [28], [33]. The

• G quadruplex structures can be resolved by helicases

  2021-10-28

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer thiostrepton australia [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and di

16174 records 588/1079 page Previous Next First page 上5页 586587588589590 下5页 Last page